Selenium Drops 50mL
Orthoplex
Selenium is an antioxidant and may help to support a healthy immune system. See your healthcare practitioner to determine if you need additional selenium.
Gluten FreeEgg FreeDairy FreeVegetarian-
Product Details
- Selenium is a major antioxidant trace element
- Selenium is a co-factor of glutathione peroxidase
- Selenium may help support a healthy immune system
Pack Size
50 Liquid (ml)
Adult Dose
Take 1-2 drops daily, in water or juice, or as recommended by your healthcare practitioner.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight.
Indications
Excipients
Ethanol, purified water.
Warning
Keep out of reach of children.This health supplement is not be used as a substitute for a varied diet. This product is Exclusively a HEALTH SUPPLEMENT and NOT INTENDED TO DIAGNOSE, TREAT, CURE OR CORRECT ANY DISEASE. This medicine contains selenium which is toxic in high doses. A daily dose of 150 micrograms for adults of selenium from dietary supplements should not be exceeded. Contains 25% v/v ethanol.
Each dose contains
| Selenomethionine | 25.0mcg |
| equiv. Selenium | 10.0mcg |
Theoretically, selenium might prolong the sedating effects of barbiturates.<br> Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates (14601,14602). Selenium seems to prolong the sedative effect of pentobarbital in animal models (14601).
14601
Debski B, Milner JA. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. J Nutr Biochem 2004;15:548-53.
14602
Ishikawa M, Sasaki M, Koiwai K, et al. Inhibition of hepatic mixed-function oxidase enzymes in mice by acute and chronic treatment with selenium. J Pharmacobiodyn 1992;15:377-85.
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.<br> Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity (14540). Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation (74406).
14540
Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96.
74406
Salonen, J. T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status. Am.J Clin.Nutr. 1991;53(5):1222-1229.
Theoretically, selenium might interfere with warfarin activity. <br> Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors (14541). Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity (14540).
14540
Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96.
14541
Davila JC, Edds GT, Osuna O, Simpson CF. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. Am J Vet Res 1983;44:1877-83.
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy. <br> In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system (74483,74445).
74445
Peretz, A., Neve, J., Desmedt, J., Duchateau, J., Dramaix, M., and Famaey, J. P. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am.J Clin.Nutr. 1991;53(5):1323-1328.
74483
Kiremidjian-Schumacher, L., Roy, M., Wishe, H. I., Cohen, M. W., and Stotzky, G. Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells. Biol.Trace Elem.Res. 1994;41(1-2):115-127.
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.<br> Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels (14544,14545,14546,101343). It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium (14545).
14544
Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988;73:163-5.
14545
Lloyd B, Lloyd RS, Clayton BE. Effect of smoking, alcohol and other factors on the selenium status of a healthy population. J Epidemiol Commun Health 1983;37:213-7.
14546
Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32.
101343
Fallah S, Sani FV, Firoozrai M. Effect of contraceptive pill on the selenium and zinc status of healthy subjects. Contraception. 2009;80(1):40-3.
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels. <br> A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease (7388,11537). It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.
7388
Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93.
11537
Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6.
Full Reference List
Rating System Description
Do not use combination; contraindicated; strongly discourage patients from using this combination; a serious adverse outcome could occur.
Use cautiously or avoid combination; warn patients that a significant interaticon or adverse outcome could occur.
Be aware that there is a chance of an interaction; advise patients to watch for warning signs of a potential interaction.
Likelihood of Occurrence
Likely: Well‑controlled human studies have demonstrated existence of this interaction.
Probable: Interaction has not been documented in well‑controlled studies, however interaction has been demonstrated in human studies or in controlled animal studies plus multiple case reports.
Possible: Interaction has been documented in animal or in vitro research, or interaction has been documented in humans but is limited to case reports or conflicting clinical research.
Unlikely: Interaction has been demonstrated in animal or in vitro research but has been shown not to occur in humans.
Severity
High: Life threatening or requires medical intervention to prevent a serious adverse event.
Moderate: Worsened clinical status and/or requires medication adjustment.
Mild: May cause minor clinical side effects. Unlikely to require medication adjustment.
Insignificant: Drug or supplement levels may be affected but will not cause clinical effects.
Level of Evidence
A: High-quality randomized controlled trial(RCT).
A: High-quality meta-analysis (quantitative systematic review)
B: Nonrandomized clinical trial
B: Nonquantitative systematic review
B: Lower quality RCT
B: Clinical cohort study
B: Case-control study
B: Historical control
B: Epidemoilogic study
C: Consensus
C: Expert opinion
D: Acecdotal evidence
D: In vitro or animal study
D: Theoretical based on pharmacology
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Disclaimer: This information on interactions is licensed from the TRC Natural Medicines Database. Neither Bio Concepts nor TRC are providing medical, clinical or other advice and nothing should be interpreted as constituting such advice. Currently this does not check for drug-drug or supplementsupplement interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgement is necessary.
Contraindications*:
Pregnancy & Lactation: Contact Supplier
*Information taken from Natural Medicines Database regarding “Major” contraindications related to active ingredients only and accurate as of October 2021. Please refer to Natural Medicines Database for more information.