Glycine 250g

Orthoplex

Glycine is a non-essential amino acid. Glycine may assist in neurotransmitter function, energy metabolism and maintaining muscle tissue. Glycine plays an integral role in protein synthesis. Supplementation may assist the function of the central nervous system and digestive system.

Gluten Free
Egg Free
Dairy Free
Vegan
Vegetarian
    Product Details

    Pack Size
    250g

    Adult Dose
    Take 1/3 of a teaspoon per day (approx. 1500mg) or as recommended by your registered healthcare practitioner (1 metric teaspoon (5mL) is approximately 4.1g).

    BIO

    Storage
    Store below 25°C in a cool, dry place, away from direct sunlight.

    Indications

      Contraindications

      • No contraindications
      • Pregnancy and lactation: not advised due to insufficient safety data

      Contraindications are taken from Natural Medicines database and are correct as of March 2019.

    Excipients
    Nil

    Warning
    This food is not a sole source of nutrition and should be consumed in conjunction with a nutritious diet as well as an appropriate physical training or exercise program. Not suitable for children under 15 years of age or pregnant women. Should only be used under medical or dietetic supervision. Formulated supplementary Sports Food.

    Ingredients

    Serving per package: Approximately 167 - Serving size: 1500mg

    Glycine 1500.0mg
    Drug Interactions
    Significance
    Ingredient
    Interaction Descriptions
    Moderate
    GLYCINE
    (Glycine)
    Be cautious with this combination.
    View Interactions:
    Moderate

    CLOZAPINE (Clozaril)

    Be cautious with this combination.

    Moderate

    CLOZAPINE (Clozaril)

    Be cautious with this combination.

    Moderate

    CLOZAPINE (Clozaril)

    Be cautious with this combination.

    Severity: mild
    Occurrence: probable
    Level of Evidence: B

    Glycine can make symptoms worse when given with clozapine (Clozaril) in patients with schizophrenia (10253). Although this effect has not been reported with other atypical antipsychotic agents, glycine should be used cautiously with all atypical antipsychotics.

    References

    10253

    Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7..


    Full Reference List

    10253
    Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7..

    Rating System Description

    Level of Significance: Stop‑Light Rating System Occurrence/Severity
    Major

    Do not use combination; contraindicated; strongly discourage patients from using this combination; a serious adverse outcome could occur.

    Moderate

    Use cautiously or avoid combination; warn patients that a significant interaticon or adverse outcome could occur.

    Minor

    Be aware that there is a chance of an interaction; advise patients to watch for warning signs of a potential interaction.

    Likelihood of Occurrence

    Likely: Well‑controlled human studies have demonstrated existence of this interaction.

    Probable: Interaction has not been documented in well‑controlled studies, however interaction has been demonstrated in human studies or in controlled animal studies plus multiple case reports.

    Possible: Interaction has been documented in animal or in vitro research, or interaction has been documented in humans but is limited to case reports or conflicting clinical research.

    Unlikely: Interaction has been demonstrated in animal or in vitro research but has been shown not to occur in humans.

    Severity

    High: Life threatening or requires medical intervention to prevent a serious adverse event.

    Moderate: Worsened clinical status and/or requires medication adjustment.

    Mild: May cause minor clinical side effects. Unlikely to require medication adjustment.

    Insignificant: Drug or supplement levels may be affected but will not cause clinical effects.

    Level of Evidence

    A: High-quality randomized controlled trial(RCT).

    A: High-quality meta-analysis (quantitative systematic review)

    B: Nonrandomized clinical trial

    B: Nonquantitative systematic review

    B: Lower quality RCT

    B: Clinical cohort study

    B: Case-control study

    B: Historical control

    B: Epidemoilogic study

    C: Consensus

    C: Expert opinion

    D: Acecdotal evidence

    D: In vitro or animal study

    D: Theoretical based on pharmacology


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    Disclaimer: This information on interactions is licensed from the TRC Natural Medicines Database. Neither Bio Concepts nor TRC are providing medical, clinical or other advice and nothing should be interpreted as constituting such advice. Currently this does not check for drug-drug or supplementsupplement interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgement is necessary.